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Chirality Transfer electron microscopy liquid phase TEM structure determination

In nature, we often see seemingly disordered (partially organized) patterns such as zebra stripes, coccoliths, corals, etc. which are aesthetically pleasing. Such patterns result from simple, non-linear rules of self-replicating building units across multiple length scales to give rise to complex morphologies that demonstrate unpredictable chemical, optical and mechanical properties. However, mimicking nature’s complexity from the nano-macro scale by the computational design of thermodynamical and kinetical pathways remains a challenge. The barrier between accurate predictions and rapid realization of complex materials lies in the gap in understanding spatial and temporal variations of interaction forces at play during growth and self-assembly. Our research interests are centered around understanding and manipulating nanoscale colloidal interactions characterized via liquid-phase transmission electron microscopy (LPTEM) and multi-modal scattering techniques to investigate and intervene at early crystal growth and self-assembly stages.

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Current Research -  We have demonstrated through key studies that, informed intervention at the early stages of crystal growth lead to (i) record-breaking membrane performance, (ii) hierarchically complex chiral micro-particles and, (iii) tunable chiral metamaterials. These studies leverage the synergistic application of state-of-the-art characterization, solution chemistry, and computational tools across multiple length scales towards a unified understanding of non-classical growth.

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Moving forward - We want to pose the following challenges –

  • Can we push the limits of characterization techniques (such as TEM) to study active nucleation events?

  • Can we discern and control the driving forces that guide the disorder to order transitions?

  • Can we create systems that combine optical, mechanical and separation properties within a single package?

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Exploration of these questions will result in programmable platforms with far-reaching advances in sustainable manufacturing of materials for healthcare, diagnostics, and optoelectronics.

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